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recombinant paraoxonase 1
- Development stage
- Preclinical
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Recombinant paraoxonase 1 (rHuPON1) is a biologic therapeutic enzyme being developed as a catalytic bioscavenger for the treatment and prophylaxis of organophosphate poisoning, including exposure to nerve agents and insecticides. It is a calcium-dependent hydrolytic enzyme naturally associated with high-density lipoproteins (HDL) in blood plasma. The enzyme functions by hydrolyzing and detoxifying neurotoxic organophosphates and insecticide metabolites. Beyond its role as a bioscavenger, rHuPON1 has potential applications in cardiovascular disease due to its ability to hydrolyze oxidized phospholipids and in oncology, specifically hepatocellular carcinoma, where it may act as a metabolic regulator to counteract immunosuppression by promoting the degradation of HIF-1α.
- Other names
- recombinant human paraoxonase 1PON1PON-1PON 1
02
Targets
OxPL (Oxidized phospholipid)
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