recombinant poliovirus vaccine vector

Recombinant poliovirus vaccine vector is a live, replication-competent **vaccine platform** derived from poliovirus (commonly Sabin 1 strain) genetically engineered to carry and express foreign antigenic sequences from other pathogens or tumors. The inserted sequences are typically flanked by poliovirus protease recognition sites to ensure correct processing into mature viral proteins and target antigens. Upon inoculation, the recombinant virus replicates in host cells, resulting in robust induction of both humoral and cellular immune responses—including cytotoxic T lymphocytes—against the foreign antigen. The platform enables multivalent vaccine design and can be engineered for genetic stability depending on the insert properties (notably high G/C content improves insert stability). The technology is researched as a means for delivering vaccine antigens for various infectious diseases (e.g., HIV, HBV, HCV, SIV) and cancer antigens[1][2][3].

Other names

recombinant poliovirus vectorchimeric poliovirus vaccine vector