recombinant SLIT2 peptide

Recombinant SLIT2 peptide (or protein) is a recombinant version of the human Slit Guidance Ligand 2 (SLIT2) glycoprotein, a secreted extracellular matrix protein that plays a key role in axon guidance, cell migration, and angiogenesis. SLIT2 acts primarily by binding to Roundabout (ROBO) receptors, particularly ROBO1 and ROBO2. In oncology, SLIT2 has been shown to function as a context-dependent tumor suppressor. In acute myeloid leukemia (AML), SLIT2 expression is often downregulated, and treatment with recombinant SLIT2 peptide has been shown to exert cytostatic effects, inhibiting leukemic cell proliferation and delaying leukemogenesis in vivo. It has also been investigated in preclinical models of breast cancer, lung cancer, glioblastoma, and neonatal brain injuries such as germinal matrix hemorrhage and hypoxic-ischemic encephalopathy.

Other names

recombinant human SLIT2recombinant human SLIT2 proteinrecombinant Slit Guidance Ligand 2recombinant SLIT2recombinant SLIT2 proteinrecombinant Slit2-NrSlit2rSlit-2rSlit 2rSlit2-NrSlit-2-NrSlit 2-N