Drug intelligence / Profile preview

rectal dexmedetomidine

Development stage
Unknown
Lead developer
Assiut University
Modality
Small Molecules
Administration
Rectal
01

Overview

DEX-Rectal is a plain rectal suppository formulation of dexmedetomidine, a selective alpha-2 adrenergic receptor agonist. It is being evaluated by Assiut University in a Phase 2/3 clinical trial (NCT05340725) as an active comparator against rectal dexmedetomidine niosomes (DEX-Nano-Rectal) and intravenous dexmedetomidine (DEX-IV) for postoperative analgesia in pediatric cancer patients undergoing bone marrow biopsy and aspiration procedures.

Other names
DEX-Rectaldexmedetomidine rectalrectal dexmedetomidine
02

Targets

ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)ADRA1A (α1A)

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