red blood cell transfusion (University of North Carolina at Chapel Hill)

Red blood cell (RBC) transfusion is a standard clinical intervention used in the management of sickle cell disease (SCD) to increase oxygen-carrying capacity and reduce the concentration of sickle hemoglobin (HbS). This specific entry refers to the 'Age of Blood in Sickle Cell Transfusion' study (NCT03704922), a randomized Phase 2/3 trial led by the University of North Carolina at Chapel Hill. The trial investigates the impact of RBC storage duration, comparing 'older' units (stored for 30 days or more) to 'fresher' units (stored for 10 days or less) in adult SCD patients receiving chronic outpatient transfusions. The study aims to determine if older RBC units contribute to increased inflammation, monocyte/macrophage activation, and higher infection rates due to biochemical changes during storage, such as phosphatidylserine expression and the release of non-transferrin bound iron (NTBI).

Other names

Age of Blood in Sickle Cell TransfusionRBC transfusiontransfusion-University of North Carolina, Chapel Hill-sickle cell disease