Drug intelligence / Profile preview

red clover oil

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Red clover oil is an oil derived from the seeds or flowers of the red clover plant (Trifolium pratense), which is a legume native to Europe, Asia, and North Africa. The oil contains a variety of bioactive compounds, most notably *isoflavones* (such as biochanin A, formononetin, daidzein, genistein), which are classified as phytoestrogens due to their ability to weakly mimic estrogenic activity in the body[1][5][7]. Red clover oil, like other red clover extracts, has been traditionally used as a dietary supplement or herbal remedy for menopausal symptoms (such as hot flushes), cardiovascular support, skin health, and respiratory disorders, although clinical evidence for these applications is limited or mixed[1][3][5]. Potential mechanisms attributed to its isoflavone content include estrogen receptor modulation, anti-inflammatory effects, and possible lipid-lowering properties[1][3][5][7]. Red clover oil is not considered an essential nutrient, and there are no established deficiency states. The use of red clover oil is generally considered safe for short-term use but is contraindicated or discouraged in pregnant and breastfeeding women, children, and people with hormone-sensitive conditions due to its phytoestrogenic activity[1][5][6].

Brand names
red clover oil
Other names
red clover seed oilTrifolium pratense oil
02

Targets

ESR1 (ERα)AHR (Aryl hydrocarbon receptor)ESR2 (ERβ)COX

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