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Red Heart Pill 2b

Development stage: Phase 2
Lead developer: Dr. Reddy's Laboratories
Modality: Small Molecules
Administration: Oral

Overview

Red Heart Pill 2b is a fixed-dose combination polypill (small molecule) manufactured by Dr. Reddy's Laboratories. It contains four active ingredients: 75 mg aspirin (antiplatelet), 20 mg simvastatin (statin), 10 mg lisinopril (ACE inhibitor), and 12.5 mg hydrochlorothiazide (thiazide diuretic). The drug is designed for the primary prevention of cardiovascular disease (CVD) in high-risk individuals by simultaneously targeting multiple risk pathways, including platelet aggregation, cholesterol biosynthesis, the renin-angiotensin system, and renal sodium reabsorption. It was evaluated in a WHO-sponsored pilot randomized clinical trial in Sri Lanka, which demonstrated the feasibility, safety, and high acceptability of this multi-drug approach for CVD prevention.

Brand names: Red Heart Pill 2b
Other names: polypillaspirin + simvastatin + lisinopril + hydrochlorothiazide

Targets

ACE (Angiotensin Converting Enzyme)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)PGHS-1 (Prostaglandin G/H Synthase 1)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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