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Red watermelon extract is a natural substance derived from the pulp of red-fleshed watermelon (Citrullus lanatus), containing a mixture of bioactive compounds, predominantly lycopene, L-citrulline, vitamins A (retinol), C (ascorbic acid), and E (α-tocopherol)[1][3]. It displays antioxidant, anti-inflammatory, and cardioprotective actions. The lycopene component can decrease the expression of pro-atherogenic proteins (e.g., PCSK9) and suppress oxidative stress and NF-κB signaling, thereby reducing inflammatory markers including TNF-α[3]. L-citrulline serves as a precursor for L-arginine and nitric oxide, supporting vascular health by promoting vasodilation and lowering blood pressure[7]. Combined, these components contribute to lowering LDL cholesterol, improving endothelial function, and potentially reducing the risk of atherosclerosis[3]. Red watermelon extract is not a single compound, drug, or pharmaceutical, but a natural multicomponent extract primarily investigated as a dietary supplement or functional food ingredient.
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