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RegenoGel-SP
- Development stage
- Unknown
- Lead developer
- ProCore Biomed
- Administration
- Intraarticular
01
Overview
**RegenoGel-SP** is an investigational intra-articular, viscoelastic hydrogel medical device developed by ProCore for moderate-to-severe osteoarthritis. It consists of fibrinogen in plasma linked to high-molecular-weight hyaluronic acid. After injection into the joint, the material is intended to form a stable viscoelastic gel through interactions with joint-surface-associated factors, providing mechanical cushioning, load dissipation, and joint lubrication rather than acting through a defined molecular receptor target. RegenoGel-SP was evaluated against hyaluronic acid in a completed Phase 1/2 randomized safety study. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02188771))
- Brand names
- RegenoGel-SP
- Other names
- RegenoGel SP
02
Targets
GPIIb/IIIa (Integrin alpha-IIb/beta-3)LAYN (Layilin)TLR2 (Toll-like Receptor 2)CD44 (CD44 antigen)αVβ3 (Integrin αVβ3)TLR4 (Toll-like receptor 4)ICAM1 (Intercellular Adhesion Molecule 1)
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