Drug intelligence / Profile preview

Regional Anesthesia-Lahey Clinic-ankle fracture

Development stage
Unknown
Lead developer
Lahey Hospital & Medical Center
Modality
Small Molecules
Administration
Perineural
01

Overview

Regional Anesthesia-Lahey Clinic-ankle fracture refers to a specific regional anesthetic intervention evaluated in a clinical trial led by the Lahey Clinic for pain management following operative treatment of ankle fractures. This intervention involves ultrasound-guided nerve blocks of the sciatic and femoral/saphenous nerves using 0.5% ropivacaine (30 mL each). Ropivacaine is a long-acting aminoamide local anesthetic that works by inhibiting sodium channels in nerve fibers, thereby blocking the conduction of nerve impulses and providing regional analgesia. The study compares this regional technique against a long-acting local anesthetic cocktail and traditional standard of care to optimize post-operative recovery and reduce opioid consumption.

Other names
Regional AnesthesiaSciatic and femoral/saphenous nerve block
02

Targets

NaV (Voltage-gated sodium channels)

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