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REGN7075 + cemiplimab + bevacizumab + trifluridine + tipiracil
- Development stage
- Unknown
- Lead developer
- Regeneron Pharmaceuticals
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
This is a **combination regimen** consisting of five agents: REGN7075 (a costimulatory bispecific antibody targeting EGFR and CD28 to restore immune sensitivity and activate T cells), cemiplimab (a PD-1 immune checkpoint inhibitor), bevacizumab (a monoclonal antibody against VEGF, inhibiting angiogenesis), and trifluridine plus tipiracil (a nucleoside analogue antimetabolite and a thymidine phosphorylase inhibitor, used as a cytotoxic chemotherapy). The combination is under investigation for the treatment of advanced/metastatic solid tumors, especially metastatic colorectal cancer (mCRC), refractory to standard therapies[1][3][5][6][10].
- Brand names
- Lonsurf
- Other names
- trifluridine/tipiracilREGN7075REGN-7075REGN 7075cemiplimabbevacizumab
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFA (Vascular endothelial growth factor A)CD28 (Cluster of Differentiation 28)DNATYMP (Thymidine phosphorylase)EGFR T790M (Epidermal growth factor receptor T790M mutant)
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