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REGN846 is a fully human monoclonal antibody that was developed for the treatment of atopic dermatitis and pruritus associated with moderate-to-severe atopic dermatitis. It was administered intravenously. The drug originated from Regeneron Pharmaceuticals and Sanofi. Its precise mechanism of action has not been publicly defined or disclosed in available sources. Clinical development included phase 1 and phase 1/2 studies in healthy volunteers and patients with refractory moderate-to-severe pruritus due to atopic dermatitis; however, all clinical development was discontinued after early-phase trials[1][3][4][5].
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