regular insulin + glucose

Regular insulin + glucose is a therapeutic combination regimen utilized in the management of diabetic pregnant women during labor. In a clinical trial context led by HaEmek Medical Center, Israel, this combination involves the constant intravenous infusion of short-acting recombinant human insulin (regular insulin) alongside a 5% glucose solution. The primary objective of this intrapartum protocol is to maintain maternal blood glucose levels within a tight euglycemic range (typically 70-100 mg/dL) to prevent maternal hyperglycemia, which is a major risk factor for subsequent neonatal hypoglycemia in infants of mothers with gestational or pregestational diabetes. Regular insulin acts as an agonist at the insulin receptor, promoting cellular glucose uptake and suppressing hepatic glucose output, while the co-administered glucose provides a controlled substrate to prevent maternal hypoglycemia during the metabolic demands of labor.

Other names

soluble insulinneutral insulinhuman insulindextrose