Reguneal HCa

**Reguneal HCa** is a two-chamber, glucose-based peritoneal dialysis solution originally developed by Baxter for continuous ambulatory peritoneal dialysis in patients with chronic renal failure. It is supplied with an acidic glucose/electrolyte chamber and a bicarbonate-containing chamber that are mixed immediately before use, producing a neutral to near-neutral dialysate with 25 mmol/L bicarbonate and 10 mmol/L lactate buffer. The design reduces glucose degradation product formation during storage and sterilization while providing osmotic ultrafiltration and diffusive solute clearance through the peritoneal membrane. BLR350 was evaluated against Dianeal PD-2 in an 8-week randomized, multicenter, open-label Phase III non-inferiority study in Japan and demonstrated non-inferior peritoneal creatinine clearance and ultrafiltration, with improved correction of metabolic acidosis. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC5648742/))

Brand names

Reguneal HCa

Other names

Reguneal HCa Peritoneal Dialysis Solutionレギュニール HCa