rehmannia glutinosa leaf extract

Rehmannia glutinosa leaf extract (RGLE) is a botanical extract derived from the leaves of Rehmannia glutinosa, a species widely used in traditional Chinese medicine. While the root is more commonly employed, recent research on the **leaf extract** has demonstrated a range of potential pharmacological effects, including anti-inflammatory, antioxidant, and immunomodulatory actions. RGLE has recently been studied as an oral supplement for conditions such as moderate to severe acne vulgaris, where it showed a clinically significant reduction in acne severity, as well as improvements in skin hydration and quality of life, without reported safety concerns. RGLE is also believed to contain active metabolites such as verbascoside, catalpol, and various glycosides and phenylethanol glycosides that may underlie its pharmacological activities. These compounds are proposed to act on molecular targets and pathways involved in inflammation, immune modulation, and skin barrier function. The exact mechanism of action in humans remains an area of ongoing research. RGLE is available commercially under brand names such as Verbasnol and is typically administered orally as a dietary supplement[9][7][5].

Brand names

Verbasnol

Other names

RGLERehmannia glutinosa leaf-based extract