Rehydragel

**Description:** Rehydragel is a highly purified, crystalline aluminum oxyhydroxide (mineralogically known as boehmite) formulated as a hydrated gel and used primarily as an adjuvant in human and veterinary vaccines[1][2][7]. It is designed to enhance the immune response by adsorbing protein antigens, thereby increasing their immunogenicity when administered with vaccines. The product has a positive charge at physiological pH, making it especially effective for binding negatively charged proteins[1]. Its high surface area (~525 m²/g) and customizable Al₂O₃ content (typically 2–10%) allow for tailored rheological properties and protein adsorption capacity[1][8]. Rehydragel does not generally induce cell-mediated immunity but promotes T-helper-2 responses with enhanced IgG1 and IgE production[2]. It is also used in blood plasma protein separation processes due to its strong protein-binding characteristics[4]. **Mechanism of Action:** As an aluminum-based adjuvant, Rehydragel works by adsorbing antigens onto its surface, facilitating their uptake by antigen-presenting cells and stimulating the humoral immune response through Th2 pathway activation. **Primary Indications:** - Adjuvant in human vaccines (e.g., HPV, pneumococcal, influenza) - Veterinary vaccine adjuvant (e.g., rabies, poultry vaccines) - Blood plasma protein separation for therapeutic applications[1][7]

Brand names

RehydragelRehydragel CGRehydragel LVRehydragel ABRehydragel HPARehydragel HSRehydragel HS 1.3Rehydragel HS 1.5Rehydragel LV-SRehydragel PMRehydragel SP

Other names

aluminum hydroxide gel (for vaccine adjuvant use)crystalline aluminum oxyhydroxide gel (boehmite)