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Relora is a proprietary, patent-pending dietary supplement that is a combination of two standardized herbal extracts: Magnolia officinalis bark (standardized to honokiol) and Phellodendron amurense bark (standardized to berberine)[1][3][5][9]. It is promoted for supporting stress and anxiety relief, regulating healthy cortisol and DHEA levels, improving mood and subjective well-being, and reducing stress-related eating. The proposed mechanisms are believed to involve modulation of stress hormone levels (notably reducing cortisol), and interaction with central nervous system receptors such as GABA and the serotonin transporter, resulting in anxiolytic and mood-stabilizing effects[1][3][5][9]. Relora does not typically cause sedation and is generally considered safe and well-tolerated in studies, although minor adverse effects have been reported rarely[2][3][4][8]. It is not intended to diagnose, treat, cure, or prevent any disease and is sold as a dietary supplement rather than a pharmaceutical drug[1]. Relora is developed by Next Pharmaceuticals and is manufactured and distributed by several dietary supplement companies.
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