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REMfresh
- Development stage
- Unknown
- Lead developer
- Physician's Seal
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
REMfresh is a continuous release and absorption (CRA) melatonin supplement designed to address occasional sleeplessness and sleep maintenance issues. Developed by Physician's Seal and marketed by Nestlé, it utilizes a patented Ion Powered Pump (IPP) delivery technology to release 99% ultrapure melatonin (branded as Ultramel) continuously for up to 7 hours. This delivery profile is intended to mimic the body's natural 'Mesa Wave' pattern of melatonin secretion, which typically peaks in the middle of the night. As a non-prescription dietary supplement, it targets endogenous melatonin receptors to regulate the circadian rhythm and improve sleep quality without the grogginess often associated with immediate-release sleep aids.
- Brand names
- REMfreshREMfresh LiteREMfresh Extra StrengthREMfresh Max Strength
- Other names
- Ultramel
02
Targets
MTNR1A (MT1)MTNR1B (Melatonin Receptor 2)
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