remimazolam + alfentanil

Remimazolam + alfentanil is a pharmacological combination used for procedural sedation and analgesia, particularly in short surgical interventions such as ophthalmic procedures. Remimazolam is an ultra-short-acting benzodiazepine that functions as a positive allosteric modulator of the GABA-A receptor, providing rapid sedation and quick recovery due to its metabolism by non-specific tissue esterases. Alfentanil is a potent, short-acting synthetic opioid that acts as an agonist at the mu-opioid receptor, providing rapid-onset analgesia. The combination is designed to leverage the synergistic effects of a sedative and an analgesic to maintain hemodynamic stability and patient comfort during surgery. Clinical research conducted by institutions like Hangzhou Plastic Surgery Hospital has explored this combination as an alternative to propofol-based regimens for eye surgery.

Brand names

Rapifen

Other names

remimazolam besylate + alfentanil hydrochloride