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Drug intelligence / Profile preview
renca tumor lysate-pulsed dendritic cells
- Development stage
- Preclinical
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Intraperitoneal, Intravenous
01
Overview
Renca tumor lysate-pulsed dendritic cells are an experimental murine cancer vaccine used in preclinical research for renal cell carcinoma. The therapy involves harvesting dendritic cells and loading (pulsing) them with a lysate derived from Renca cells, a syngeneic murine renal cell carcinoma line. These antigen-presenting cells then prime T cells to recognize and attack tumor cells expressing Renca-specific antigens. Studies often explore this vaccine in combination with other immunotherapies, such as anti-CD69 antibodies, to overcome immune suppression and enhance therapeutic efficacy in tumor-bearing mice.
- Other names
- Renca tumor lysate-pulsed dendritic cellsRenca tumor lysate-pulsed DCRenca DC vaccine
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