Drug intelligence / Profile preview

Replenix Power of 3 Cream

Development stage
Phase 4
Lead developer
Topix Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

Replenix Power of 3 Cream is a high-potency topical antioxidant formulation developed by Topix Pharmaceuticals. It is designed to neutralize free radicals and visible signs of aging while soothing skin redness and inflammation. The "Power of 3" refers to its core active complex: 90% Green Tea Polyphenols (Camellia sinensis), Resveratrol, and Caffeine. Green tea polyphenols, specifically epigallocatechin gallate (EGCG), provide robust antioxidant protection and anti-inflammatory effects. Resveratrol, a polyphenol derived from grapes, acts as a potent antioxidant and SIRT1 activator to support skin health and longevity. Caffeine is included to enhance the antioxidant activity of the polyphenols and provide vasoconstrictive properties, which help reduce the appearance of redness and puffiness. This cream is frequently utilized in dermatological settings for patients with sensitive skin, rosacea, or those recovering from aesthetic procedures.

Brand names
Replenix Power of 3 CreamReplenix Power of 3 Cream with ResveratrolReplenix Power of 3 Antioxidant Cream
Other names
Replenix Power of 3
02

Targets

PDE (Phosphodiesterase family)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NF-κB

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