rescinnamine

Rescinnamine is an indole alkaloid and small molecule antihypertensive drug originally isolated from the plant *Rauwolfia serpentina* and related species[1][4][5]. It acts primarily as an angiotensin-converting enzyme (ACE) inhibitor by binding to and inhibiting ACE; this blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II[1][2][6]. The resulting decrease in angiotensin II leads to reduced aldosterone secretion and vasoconstriction—ultimately lowering blood pressure[2][6]. Rescinnamine was developed for the treatment of hypertension but has been withdrawn from many markets; its mechanism may also involve catecholamine depletion similar to reserpine due to structural similarity[3][5].

Brand names

ModerilCinnasilAnaprel

Other names

rescinnaminemethyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.0 2,10.0 4,9.0 15,20]henicosa-2(10),4(9),5,7-tetraene-19-carboxylate