resibufogenin

**Resibufogenin** is a bioactive bufadienolide steroid extracted primarily from the venom glands of certain toads of the Bufonidae family and is a main glycoside constituent in the traditional Chinese medicine Chan Su[1][7]. It exhibits **cardiotonic** properties similar to cardiac glycosides like digoxin by inhibiting the Na^+/K^+-ATPase[10]. Its mechanisms encompass induction of cell cycle arrest, apoptosis, and inhibition of cell proliferation and migration, including via proteasomal degradation of cyclin D1 and modulation of ATP1A1 signaling cascade[6][9]. Resibufogenin has demonstrated anticancer, anti-inflammatory, antiviral, vasopressor, and respiratory-therapeutic effects, and antiangiogenic activity through inhibition of VEGFR2 phosphorylation and downstream signaling[1][4]. Therapeutic areas include oncology (notably for multiple myeloma, triple-negative breast cancer, pancreatic and colorectal cancer), cardiovascular diseases (heart failure, hypertension), and respiratory disorders[1][3][4][7].

Brand names

Respigon

Other names

bufogeninbufogeninaResibufoginResibufogenin USP/EP/BPResibufogenin-RMResibufogenin 95%Resibufogenin 97%