Drug intelligence / Profile preview

resin modified glass ionomer varnish

Development stage
Phase 4
Lead developer
3M
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Dental, Topical
01

Overview

Resin modified glass ionomer varnish is a dental material designed to provide a protective and remineralizing coating on tooth surfaces, particularly for the prevention of demineralization and caries. It combines the properties of traditional glass ionomer cements (such as fluoride release) with added resins to improve handling and physical characteristics. The mechanism of action involves gradual fluoride release over several months, which helps inhibit enamel demineralization and promote remineralization. This type of varnish is used in various clinical scenarios including around orthodontic brackets to prevent white spot lesions, as a sealant for pits and fissures in molars at risk for caries, and as an adjunctive treatment for non-cavitated proximal carious lesions in children[1][2][3][4][5]. Light-curable versions (e.g., Clinpro XT) allow site-specific application with durable retention[1][5]. The product is non-invasive, easy to apply chairside, cost-effective compared to some alternatives, and has demonstrated efficacy in both clinical trials and laboratory studies[1][2][4].

Brand names
Clinpro XT varnish
Other names
RMGI varnishresin-modified glass ionomer cement varnishlight-curable resin-modified glass ionomer varnishRMGI-F varnish
02

Targets

ENO (Alpha-enolase)

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