Drug intelligence / Profile preview

resina draconis extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Resina draconis extract is a natural resinous extract obtained from the stems of Dracaena species, primarily Dracaena cochinchinensis, commonly referred to as "dragon's blood" in traditional medicine[1][2][4]. The extract is prepared from the raw resin by methods such as alcohol extraction, non-heating extraction, and ultrasonic-assisted extraction, sometimes followed by purification via macroporous resin[1]. The primary active compounds are phenolic constituents, especially flavonoids (such as loureirin A and B), as well as stilbenes, terpenoids, and steroids[1][2][4]. Pharmacological studies indicate mechanisms of action that include antithrombotic (inhibition of platelet aggregation), anti-inflammatory (suppression of pro-inflammatory cytokines), antibacterial, anti-ulcer, hepatoprotective, and antitumor effects[1][2][3][5][6]. Evidence suggests modulation of hepatocyte growth factor (HGF), tumor necrosis factor alpha (TNFα), and epidermal growth factor receptor (EGFR) signaling in liver regeneration[5], and inhibition of cancer growth possibly by affecting methyltransferase-like 3 (METTL3) and aerobic glycolysis in tumor cells[3]. Resina draconis extract is primarily used in traditional Chinese medicine for wound healing, hemostasis, treatment of injuries, gastrointestinal ulcers, and increasingly investigated as an adjunct in cancer therapy and acute/chronic liver conditions[1][2][3][5][6].

Other names
dragon's bloodDraconis Resina extractlongxuejie extractRD extractERD (ethanol extract of Resina Draconis)
02

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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