Drug intelligence / Profile preview

RespiliQ

Development stage
Preclinical
Lead developer
O11 biomedical
Modality
Small Molecules
Administration
Oral, Rectal
01

Overview

RespiliQ is an enteral carbon dioxide (CO2) absorber designed to facilitate gas exchange via the gastrointestinal tract, a concept referred to as "breathing via the gut." Developed by O11 biomedical GmbH, the product is a suspension of microspherules composed of calcium hydroxide and polyethylene, formulated in a 1.4 wt% guar gum solution. The mechanism of action involves the chemical absorption of CO2 by the calcium hydroxide within the microspherules as they transit through the gut. This non-pulmonary method of CO2 removal is intended for the management of hypercapnia and respiratory failure. Preclinical studies in large animal models (domestic pigs) have demonstrated that RespiliQ has a favorable safety profile and maintains consistent CO2 uptake efficacy over a six-week period without causing clinical abnormalities or gastrointestinal discomfort.

Brand names
RespiliQ
Other names
enteral CO2 absorber

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