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Restorative Microbiota Therapy
- Development stage
- Phase 2
- Lead developer
- University of Minnesota
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Rectal, Intracolonic, Nasogastric, Nasoduodenal
01
Overview
Restorative Microbiota Therapy (RMT) is an investigational live biotherapeutic product consisting of a standardized, oral, encapsulated formulation of freeze-dried microbiota derived from healthy, screened human donors. [5, 6] It is designed to restore a healthy gut microbiome composition. [4] It is being studied to determine if modulating the gut microbiome can enhance the efficacy of cancer treatments, particularly the combination of immune checkpoint inhibitors and chemotherapy. [12] The product described in the provided context was manufactured by the University of Minnesota's Microbiota Therapeutics Program for a clinical trial in patients with advanced Non-Small Cell Lung Cancer (NSCLC). [3, 12]
- Other names
- Fecal Microbiota TransplantFMTMicrobiota Transplant TherapyMTTIntestinal Microbiota TransplantationIMT
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