Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Restrictive fluid administration, in the context of the Tel-Aviv Sourasky Medical Center study, refers to a specific intraoperative fluid management protocol using Ringer's Lactate (RL) solution for patients undergoing video-assisted thoracic surgery (VATS) for lung resection. This regimen involves the intravenous administration of RL at a restricted rate of 2 ml/kg/hr throughout the surgery, contrasting with standard or liberal regimens that typically use higher volumes (e.g., 8 ml/kg/hr). The primary therapeutic goal of this restrictive approach is to maintain adequate systemic perfusion while minimizing the risk of fluid overload, which can lead to postoperative pulmonary complications such as acute lung injury (ALI) and pulmonary edema. By limiting the volume of crystalloids administered, the protocol aims to improve postoperative outcomes, including reduced morbidity, mortality, and shorter hospital stays for patients with lung diseases requiring surgical intervention.
Beyond the preview
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Follow clinical development from study design and recruitment through results.
Explore development by indication, patient population, and geography.
Trace asset ownership, licensing agreements, and commercial partnerships.
Explore the patent landscape and regulatory exclusivity around an asset.
Compare development programs by target, modality, and indication.
Connect source evidence and development news to your research questions.
See how Gosset can support your research on restrictive fluid administration.