Drug intelligence / Profile preview

Restylane

Development stage
Phase 4
Lead developer
Galderma
Administration
Intradermal, Submucosal
01

Overview

Restylane is a comprehensive line of injectable dermal fillers composed of hyaluronic acid, a naturally occurring polysaccharide that provides structural support and hydration to the skin. Originally developed by the Swedish biotechnology company Q-Med (now a subsidiary of Galderma), Restylane was the first stabilized hyaluronic acid filler to receive FDA approval in 2003. The product line utilizes two primary manufacturing technologies: **NASHA** (Non-Animal Stabilized Hyaluronic Acid), which creates a firmer gel for precision lifting and contouring, and **XpresHAn Technology** (also known as Optimal Balance Technology), which produces a more flexible gel designed for natural-looking results in dynamic areas of the face. Restylane is indicated for the correction of moderate-to-severe facial wrinkles and folds (such as nasolabial folds), lip augmentation, cheek enhancement, and the restoration of volume in the midface and back of the hands.

Brand names
RestylaneRestylane-LRestylane SilkRestylane LyftRestylane RefyneRestylane DefyneRestylane KysseRestylane VolymeRestylane ContourRestylane EyelightRestylane SkinboostersRestylane VitalPerlaneEmervel
Other names
瑞蓝NASHANon-Animal Stabilized Hyaluronic AcidXpresHAn TechnologyOptimal Balance TechnologyOBT
02

Targets

LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)STAB2 (Stabilin-2)RHAMM (Hyaluronan-mediated motility receptor)CD44 (CD44 antigen)ICAM1 (Intercellular Adhesion Molecule 1)

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