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resuspended umbilical cord-derived mesenchymal stromal cells (Universidad de los Andes)
- Development stage
- Unknown
- Lead developer
- Cells for Cells
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Resuspended umbilical cord-derived mesenchymal stromal cells (UC-MSCs) are a cell therapy product developed by the Universidad de los Andes, Chile, for the treatment of symptomatic knee osteoarthritis. This specific preparation represents the standard method of MSC delivery, which involves harvesting cells from the umbilical cord, expanding them in a Good Manufacturing Practices (GMP) facility, and resuspending them in a carrier solution immediately prior to intra-articular injection. The therapeutic mechanism involves the secretion of immunomodulatory and trophic factors that reduce synovial inflammation and promote a pro-regenerative environment within the joint. In clinical trials, such as the PANLAR-II study, this resuspended formulation serves as the standard-of-care comparator for a novel "ready-to-inject" cryopreserved formulation designed to simplify clinical application and enable wider access to cell therapy in facilities without specialized equipment.
- Other names
- Resuspended Umbilical cord-derived Mesenchymal Stromal Cell (MSC) productStandard UC-MSCsResuspended UC-MSCs
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