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resveratrol
- Development stage
- Phase 4
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Topical, Intravenous
01
Overview
Resveratrol is a natural polyphenolic compound belonging to the stilbenoid group, commonly found in grapes, wine, peanuts, and Japanese knotweed (*Polygonum cuspidatum*). It functions as a calorie restriction mimetic, primarily known for activating **Sirtuin 1 (SIRT1)** and **AMP-activated protein kinase (AMPK)**, which subsequently improves mitochondrial function, enhances insulin sensitivity, and reduces oxidative stress. Resveratrol has been extensively investigated for its cardioprotective, anti-inflammatory, and neuroprotective properties. Clinical development spans various indications including obesity, metabolic syndrome, hypertriglyceridemia, and type 2 diabetes. Additionally, it is used as an excipient/matrix in medical devices, such as the SeQuent Please ReX drug-coated balloon, to facilitate the delivery of antiproliferative drugs.
- Brand names
- resVidaVERI-TE Resveratrol
- Other names
- trans-resveratroltrans-3,5,4'-trihydroxystilbenePolyphenolStilbenoid白藜芦醇
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)NF-κB
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