Drug intelligence / Profile preview

resveratrol triacetate

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intraperitoneal (in Experimental Settings)
01

Overview

**Resveratrol triacetate** is a synthetic, acetylated prodrug of resveratrol with increased cell permeability and enhanced stability compared to resveratrol. It is readily hydrolyzed by esterases in vivo to yield active resveratrol. It exhibits similar biological activities to resveratrol, including antioxidant, antitumor, and radioprotective effects. Mechanistically, it can activate p53, increase p21 and p53R2, decrease PSA expression, induce cell cycle arrest, inhibit intracellular melanin synthesis, and interact with integrin αvβ3, among other pathways. Its improved pharmacokinetic properties, such as longer half-life, facilitate more effective delivery of resveratrol to tissues and increased potency in some models[2][7][9][10].

Other names
triacetylresveratrol3,5,4'-tri-O-acetylresveratroltrans-resveratrol triacetateacetyl-trans-resveratrolresveratrol 3,5,4'-triacetateacetylresveratrolacethyl resveratrolresveratrol triacetate impurityresveratroltriacetyl[2][4][7][12]
02

Targets

αVβ3 (Integrin αVβ3)

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