reteplase

Reteplase is a thrombolytic drug, often called a "clot-busting" drug, that helps the body produce a substance that dissolves unwanted blood clots. It's a non-glycosylated deletion mutein of tissue plasminogen activator (tPA) containing the kringle 2 and protease domains of human tPA. Reteplase contains 355 of the 527 amino acids of native tPA (amino acids 1-3 and 176-527) and is produced by recombinant DNA technology in E. coli. The drug works by binding to fibrin and converting plasminogen to plasmin, which then degrades the fibrin matrix of the thrombus. It is primarily used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack (acute myocardial infarction).

Brand names

RetavaseMiRel

Other names

R TPR 004