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Drug intelligence / Profile preview
retinaldehyde + glycolic acid
- Development stage
- Unknown
- Lead developer
- Laboratoires Dermatologiques Avène
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Retinaldehyde + glycolic acid (also known as RALGA) is a topical combination formulation marketed under the brand name Diacneal for the treatment of mild to moderate acne vulgaris, postinflammatory hyperpigmentation (PIH), and acne scarring. It combines 0.1% retinaldehyde, a natural precursor of retinoic acid that modulates keratinocyte differentiation and proliferation, with 6% glycolic acid, an alpha-hydroxy acid that promotes exfoliation of corneocytes. The combination is formulated as an oil-in-water emulsion at a low pH (~3.5), where glycolic acid enhances the bioavailability and skin delivery of retinaldehyde, maximizing efficacy while minimizing the irritation typically associated with high-concentration topical retinoids.
- Brand names
- DiacnealDiacnéal
- Other names
- glycolic acid + retinaldehydeRALGAretinal + glycolic acidretinaldehyde and glycolic acid
02
Targets
RAR (Retinoic acid receptor)RXRA (Retinoid X receptor alpha)TYR (Tyrosinase)
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