Drug intelligence / Profile preview

retinaldehyde + niacinamide + haritaki fruit extract

Development stage
Unknown
Lead developer
Pierre Fabre
Modality
Small Molecules
Administration
Topical
01

Overview

The combination of retinaldehyde, niacinamide, and haritaki fruit extract is a dermocosmetic anti-aging formulation developed by Pierre Fabre under the Avène brand, specifically within the Hyaluron Activ B3 line. The formulation typically contains 0.1% retinaldehyde, 2% niacinamide, and 0.1% haritaki fruit extract. Retinaldehyde serves as a direct precursor to retinoic acid, promoting cellular renewal and collagen synthesis to reduce wrinkles. Niacinamide (Vitamin B3) enhances skin barrier function and provides anti-inflammatory benefits. Haritaki fruit extract (*Terminalia chebula*) acts as an antioxidant and is included for its potential to inhibit hyaluronidase, thereby preserving natural hyaluronic acid levels in the skin. Clinical data indicates the combination is effective in improving skin firmness, texture, and radiance, and is used to maintain results following aesthetic procedures like hyaluronic acid fillers.

Brand names
Avène Hyaluron Activ B3 Multi-Intensive Night CreamAvène 0.1 cream
02

Targets

RARA (Retinoic acid receptor alpha)RARG (Retinoic acid receptor gamma)RARB (Retinoic acid receptor beta)

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