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RetinoStat
- Development stage
- Phase 1
- Lead developer
- Oxford BioMedica
- Modality
- Gene Therapies
- Administration
- Subretinal
01
Overview
**RetinoStat** is an investigational, single-administration ocular gene therapy developed by Oxford BioMedica for neovascular age-related macular degeneration. It uses an equine infectious anemia virus-based lentiviral vector to deliver expression cassettes for secreted endostatin and angiostatin following subretinal administration. The expressed proteins are intended to provide sustained local anti-angiogenic and anti-permeability activity in the retina and choroid. In a completed Phase I study in advanced neovascular AMD, the product showed dose-dependent, durable intraocular expression of both transgene products and an acceptable safety profile, but clinical efficacy in the late-stage population was limited. ([investegate.co.uk](https://www.investegate.co.uk/announcement/rns/oxford-biomedica--oxb/publication-of-retinostat-oxb-201-phase-i-study/4745078))
- Brand names
- RetinoStat
- Other names
- RetinoStat
02
Targets
ANXA2 (Annexin A2)
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