Drug intelligence / Profile preview

retinyl acetate

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral, Parenteral, Topical
01

Overview

Retinyl acetate is a synthetic acetate ester of retinol (vitamin A alcohol) and a lipid-soluble *provitamin A* compound used as a dietary supplement or food additive to fortify foods with vitamin A[4][2][3]. After ingestion, retinyl acetate is hydrolyzed in the intestine to release retinol, which is then absorbed and converted in the body to retinal (necessary for vision), and retinoic acid (which acts as a ligand for retinoic acid receptors, regulating gene transcription critical for cell differentiation, immune function, and epithelial maintenance)[1][4]. Used primarily for vitamin A supplementation or to treat/prevent vitamin A deficiency, it has good stability compared to retinol.

Brand names
MyvakMyvaxCrystaletsDavitan A 650
Other names
retinol acetateall-trans-retinol acetateall-trans-retinyl acetateall-trans-vitamin A acetatetrans-retinyl acetatevitamin A acetatevitamin A1 acetatetrans-vitamin A acetatevitamin A alcohol acetate
02

Targets

RPE65 (Retinal pigment epithelium-specific 65 kDa protein)RARA (Retinoic acid receptor alpha)RARG (Retinoic acid receptor gamma)RARB (Retinoic acid receptor beta)

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