Drug intelligence / Profile preview

Retivance

Development stage
Unknown
Lead developer
Obagi
Modality
Small Molecules, Peptides
Administration
Topical
01

Overview

Retivance is a topical skin rejuvenation formulation developed by Obagi Medical Products, primarily utilized for its anti-aging and skin-smoothing properties. The formulation's core active ingredient is retinaldehyde (0.1%), a stable precursor to retinoic acid that promotes cellular turnover and collagen production with a lower irritation profile compared to traditional tretinoin. It also incorporates Palmitoyl Tripeptide-5, a synthetic peptide designed to mimic the body's natural mechanism for activating Transforming Growth Factor-beta (TGF-beta), thereby stimulating collagen synthesis. Complementary ingredients such as Chamomilla recutita flower extract provide anti-inflammatory benefits to soothe the skin and reduce visible redness. Retivance is marketed to improve the appearance of fine lines, wrinkles, and skin texture while being suitable for sensitive skin types.

Brand names
RetivanceObagi Clinical Retivance Skin Rejuvenating Complex
Other names
Retivance Skin Rejuvenating Complex
02

Targets

NR superfamily (Nuclear receptor superfamily)

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