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retlirafusp alfa + nab-paclitaxel
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Retlirafusp alfa + nab-paclitaxel is a combination therapy being investigated for the treatment of breast cancer, particularly triple-negative breast cancer (TNBC). Retlirafusp alfa (SHR-A1811) is a next-generation antibody-drug conjugate (ADC) targeting HER2, consisting of a humanized anti-HER2 monoclonal antibody linked to a potent topoisomerase I inhibitor payload (an exatecan derivative) via a cleavable linker. Nab-paclitaxel is an albumin-bound nanoparticle formulation of paclitaxel that inhibits microtubule dynamics. The combination aims to leverage the targeted delivery and bystander effect of the ADC alongside the cytotoxic effects of the taxane to improve outcomes in patients with HER2-expressing or HER2-low breast cancers.
- Other names
- SHR-A1811 plus nab-paclitaxelSHR-A-1811 plus nab-paclitaxelSHR-A 1811 plus nab-paclitaxelretlirafusp alfa plus nanoparticle albumin-bound paclitaxel
02
Targets
CD274 (Programmed cell death protein 1 ligand 1)TUBB (Tubulin (alpha and beta subunits))ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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