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retlirafusp alpha
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Retlirafusp alpha (SHR-1701) is a bifunctional fusion protein developed by Jiangsu Hengrui Pharmaceuticals. It consists of a humanized monoclonal antibody targeting programmed death-ligand 1 (PD-L1) fused to the extracellular domain of the human transforming growth factor-beta receptor type II (TGFBR2). This dual-action molecule is designed to simultaneously inhibit the PD-1/PD-L1 checkpoint pathway and sequester TGF-beta within the tumor microenvironment. By blocking these two major immunosuppressive pathways, retlirafusp alpha aims to restore anti-tumor immune responses and overcome resistance to standard checkpoint inhibitors. It is currently being evaluated in various clinical trials, particularly for gastrointestinal cancers and non-small cell lung cancer.
- Other names
- retlirafusp alfaanti-PD-L1/TGF-beta RII fusion proteinPD-L1/TGF-beta trap
02
Targets
TGFB2 (Transforming growth factor beta 2)TGFB3 (Transforming growth factor beta 3)TGFB1 (Transforming growth factor Beta-1 proprotein)CD274 (Programmed cell death protein 1 ligand 1)
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