reuterin

Reuterin is a naturally occurring, broad-spectrum antimicrobial compound produced by the probiotic bacterium *Limosilactobacillus reuteri* (formerly *Lactobacillus reuteri*) during the anaerobic fermentation of glycerol. It is not a single substance but a dynamic multi-component system consisting of 3-hydroxypropionaldehyde (3-HPA), its hydrate, its dimer, and acrolein. Reuterin exhibits potent inhibitory activity against a wide range of Gram-positive and Gram-negative bacteria, as well as yeasts, molds, and protozoa. Its mechanism of action involves inducing oxidative stress and inhibiting ribonucleotide reductase, which interferes with DNA synthesis. While primarily studied as a food preservative and a key factor in the probiotic benefits of *L. reuteri*, recent research has highlighted its potential anti-inflammatory and anti-cancer properties, particularly in colorectal cancer models where it may be delivered via engineered probiotic strains.

Other names

3-hydroxypropionaldehyde3-HPAbeta-hydroxypropionaldehyde