rev-erb-alpha inhibitor

Rev-erb-alpha inhibitors are a class of small molecules that target the nuclear receptor Rev-erb-alpha (NR1D1), a key component of the molecular circadian clock. While Rev-erb-alpha typically acts as a transcriptional repressor to regulate metabolism and circadian rhythms, recent research (notably from UC Davis and the Salk Institute) has identified its role in driving tumor lineage plasticity in advanced, therapy-resistant prostate cancer. By inhibiting Rev-erb-alpha, these compounds can reverse chromatin bivalency resolution, thereby suppressing the activation of neurodevelopmental and stemness programs that allow cancer cells to evade androgen receptor (AR) targeting therapies.

Other names

NR1D1 inhibitorNR-1D1 inhibitorNR 1D1 inhibitorREV-ERBA inhibitor