reveromycin a

**Reveromycin A** is a natural polyketide compound isolated from *Streptomyces reveromyceticus*. It is a selective inhibitor of eukaryotic cytoplasmic **isoleucyl-tRNA synthetase**, which blocks protein synthesis in target cells. It exhibits potent effects against mature osteoclasts by inducing their apoptosis, leading to inhibition of bone resorption. Reveromycin A has demonstrated **antiresorptive** activity in vitro and in animal models, with potential applications in the treatment of osteoporosis, periodontitis, and bone metastasis of tumors. Its unique selectivity is due to its preferential uptake into osteoclasts in acidic environments, characteristic of activated bone-resorbing osteoclasts. Additionally, reveromycin A shows antifungal, antiproliferative, and cell cycle (G1 phase) inhibitory activities and is being explored as a biochemical probe and candidate therapeutic[1][3][5][7][9].

Other names

RM-A