Drug intelligence / Profile preview

rexlemestrocel-l + hyaluronic acid

Development stage
Phase 3
Lead developer
Mesoblast
Modality
Cell Therapies, Hydrogel Systems → Drug Delivery Systems
Administration
Intradiscal, Intramyocardial, Intracoronary, Intravenous
01

Overview

Rexlemestrocel-L + hyaluronic acid is a combination therapy consisting of an investigational, allogeneic human bone marrow-derived mesenchymal precursor cell (MPC) product (rexlemestrocel-L) delivered with hyaluronic acid as a carrier. Rexlemestrocel-L is designed to modulate inflammation and promote tissue repair, while hyaluronic acid serves as a delivery agent and may provide additional chondroprotective, anti-inflammatory, and analgesic effects. The combination has been studied primarily for chronic low back pain associated with degenerative disc disease, where it has demonstrated significant and durable reductions in pain and improvements in function compared to controls. Mesoblast is the primary developer of this therapy[2][5][7].

Other names
allogeneic human bone marrow-derived mpcallogeneic mesenchymal precursor cellimmunoselected stro-3+ allogenic mesenchymal precursor cells
02

Targets

CD44 (CD44 antigen)

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