Drug intelligence / Profile preview

reynoutria japonica aqueous extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Reynoutria japonica aqueous extract is a **botanical extract drug candidate and traditional medicine-derived preparation** obtained from the dried roots and rhizomes of *Reynoutria japonica* Houtt. It is a complex multicomponent mixture rather than a single defined molecular entity, with reported constituents including anthraquinones such as emodin, stilbenes such as polydatin and resveratrol, and flavonoids. Preclinical studies, including a mouse study in ulcerative colitis, suggest that its pharmacology is pleiotropic and may involve modulation of gut microbiota composition and metabolism, reduction of inflammatory signaling, restoration of intestinal mucosal integrity, and increased short-chain fatty acid production. Based on the provided evidence, it appears to be an investigational research extract used in preclinical and traditional medicine contexts rather than a commercially developed pharmaceutical product with a clearly identified sponsor, brand, single target, or established regulatory approval pathway.

Other names
aqueous extract of Reynoutria japonicaReynoutria japonica extractPolygonum cuspidatum aqueous extract
02

Targets

TYR (Tyrosinase)MMP12 (Macrophage Metalloelastase)ButyrylcholinesteraseAcetylcholinesteraseElastase

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