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rFPV-HIV-AE
- Development stage
- Phase 2
- Lead developer
- The Kirby Institute
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
rFPV-HIV-AE is a recombinant, non-replicating fowlpox virus (rFPV) vector-based vaccine candidate developed by the Kirby Institute for the prevention of HIV-1 infection. It is specifically engineered to deliver HIV-1 genes from the AE clade, which is the predominant subtype in Southeast Asia. The vaccine is designed to be used as a booster in a heterologous prime-boost immunization strategy, typically following three priming doses of the pHIS-HIV-AE DNA vaccine. By using a viral vector to express HIV-1 antigens in vivo, the vaccine aims to stimulate both cellular (T-cell) and humoral (B-cell) immune responses to provide protection against HIV-1 infection.
- Other names
- recombinant fowlpox virus-based HIV vaccinerFPV-HIV-AE boost
02
Targets
HIV-1 CRF01_AE antigens
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