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RG-19

Development stage: Unknown
Lead developer: Hangzhou Ronggu Biotechnology
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Gene Silencing → Gene Therapies, Gene Editing → Gene Therapies, Gene Addition/Replacement → Gene Therapies
Administration: Intravenous

Overview

RG-19 (also known as RG-019) is an investigational, off-the-shelf (universal) chimeric antigen receptor natural killer (CAR-NK) cell therapy targeting CD19, developed by Hangzhou RonGu Biotechnology. The therapy is engineered using lentiviral gene transfer to express a CD19-directed CAR, enabling the modified NK cells to selectively recognize and eliminate CD19-positive B-cells. RG-19 is being developed for the treatment of B-cell malignancies, including B-cell non-Hodgkin lymphoma (B-NHL) and acute lymphoblastic leukemia (ALL), as well as autoimmune diseases such as systemic lupus erythematosus (SLE).

Targets

CD19 (B lymphocyte antigen CD19)

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