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RG-1970

Development stage: Unknown
Lead developer: Hangzhou Ronggu Biotechnology
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

RG-1970 is a dual-targeted chimeric antigen receptor natural killer (CAR-NK) cell therapy developed by Hangzhou RonGu Biotechnology, in collaboration with Belief BioMed and Innovent Biologics. It is designed using a lentiviral vector and a nanobody-based CAR structure to simultaneously target CD19 and CD70 on malignant cells, mediating cytotoxic killing. RG-1970 is being developed for the treatment of B-cell non-Hodgkin lymphoma (B-NHL), with investigator-initiated trials (IIT) ongoing since the second quarter of 2023.

Other names: CD19/CD70 CAR-NK cells therapyCD19/CD70 CAR-NK therapy

Targets

CD27 (Cluster of Differentiation 27)CD70 (Cluster of Differentiation 70)CD19 (B lymphocyte antigen CD19)

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