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RG-19BCMA

Development stage: Preclinical
Lead developer: Hangzhou Ronggu Biotechnology
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

RG-19BCMA is a preclinical-stage dual-target chimeric antigen receptor natural killer (CAR-NK) cell therapy being developed by Hangzhou RonGu Biotechnology for the treatment of multiple myeloma. The therapy utilizes a nanobody co-expression CAR platform to simultaneously target B-cell maturation antigen (BCMA) and CD19. By co-targeting both antigens, RG-19BCMA is designed to enhance the recognition and elimination of antigen-positive malignant myeloma cells, potentially overcoming antigen escape and improving therapeutic efficacy compared to single-target therapies.

Targets

CD19 (B lymphocyte antigen CD19)BCMA (B-cell maturation antigen)

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