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RG-70
- Development stage
- Unknown
- Lead developer
- Hangzhou Ronggu Biotechnology
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
RG-70 is an investigational, universal chimeric antigen receptor natural killer (CAR-NK) cell therapy developed by Hangzhou RonGu Biotechnology. It is engineered using a lentiviral vector and a nanobody-based CAR construct to target CD70, a tumor-associated antigen frequently overexpressed in various hematological malignancies. By targeting CD70, RG-70 aims to selectively recognize and eliminate CD70-expressing malignant cells. The therapy is currently being evaluated in investigator-initiated trials (IIT) for the treatment of T-cell lymphoma, T-cell leukemia, acute myeloid leukemia (AML), and T-cell non-Hodgkin lymphoma (T-NHL).
02
Targets
CD70 (Cluster of Differentiation 70)
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